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Medical Dictionary

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Haploinsufficiency

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means:
Haploinsufficiency A situation in which the total level of a gene product (a particular protein) produced by the cell is about half of the normal level and that is not sufficient to permit the cell to function normally. Another way to define haploinsufficiency is as a condition that arises when the normal phenotype requires the protein product of both alleles, and reduction of 50% of gene function results in an abnormal phenotype. Haploinsufficiency can be due to a number of problems. One of the two copies of the gene may be missing due to a deletion. A mutation (change) in the gene may have wiped out production of message. Or the message or the protein produced by the cell may be unstable or degraded by the cell.
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"Haploinsufficiency" shown in the following materials:
Teeth can be saved for future stem cell harvesting by PRWEB press release FERNDALE, USA: Recent research has shown that normally shedding baby teeth and extracted wisdom teeth can be a source of stem cells[...]

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Researchers from Queen Mary, University of London, have developed a new gene test that detects precancerous cells in patients with mouth lesions. They think that the test could offer the possibility of early and[...]

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